Abstract

1. Abstract
1.1. Background: P-53 gene mutation is the most common genetic abnormality of cancers regarding low survival and non-response to classical conventional chemotherapy in treatments of patients.
1.2. Method: Identifying P-53 gene mutation with the p-53 protein isoform was detected by the ELISA method to patients with Chronic Lymphocytic Leukemia, (CLL). Also, levels of energy in cells, especially in CLL, due to the dis-regulation of P-53 genes, were measured using the bio-luminescence method, with adenozin- three-phosphate, (ATP), kits, running an Analyzer of bio-luminescence LKB.