Abstract

1. Abstract
1.1. Background: Knee osteoarthritis (KOA) is one of the most widespread degenerative diseases that lead to pain and disability. Oral NSAIDs and Intra-articular corticosteroid injections are usually used to relieve symptoms in patients with knee osteoarthritis. In this study, we assessed the safety and efficacy of the combination of autologous adipose-derived mesenchymal stem cells (AD-MSC) that is mechanically treated with a stromal vascular fraction (SVF) and bone marrow aspirate concentrate (BMAC) injections on pain reduction and improvement of functioning in patients with KOA. The aim was to gain more information as there is a lack of research on combinational orthobiologic treatment.