
1. Abstract
1.1. Background: Olfactory neuroblastoma or esthesioneuroblastoma (ENB) is a rare malignant tumor arising from the olfactory epithelium, which is commonly treated by surgery and radiotherapy (RT). However, the benefit of chemotherapy has not been clearly addressed. Therefore, this case report focused on the potential role of chemotherapy in late-stage ENB patients with multiple and recurrent metastasis.