Abstract

1. Abstract

Crohn's disease is a chronic inflammatory entity that affects the gastrointestinal tract transmurally in variable pattern. It is classified according to age of presentation, location, behavior and severity. This case illustrates a patient with severe Crohn's disease with poor prognostic characteristics that was treated with two biologics infliximab and Ustekinumab. Ustekinumab resulted in anorectal and colonic strictures and this is the first case to report this complication in Ustekinumab. The colonic stricture responded to dilatation but the anorectal stricture showed partial response to dilatation.