Abstract

1. Abstract
1.1. Objectives
To investigate whether treatment in SLE patients during pregnancy may influence the occurrence of adverse pregnancy outcomes (APO).
1.2. Methods
We performed a monocentric observational study in SLE pregnant patients prospectively followed at the ‘high risk obstetrics’ multidisciplinary outpatient clinic at San Raffaele Hospital, Milan, Italy from January 2003 to June 2021. We collected data from 58 SLE patients and 79 pregnancies. We also compared maternal and neonatal outcomes between pregnancies occurring before and after 2010.
1.3. Results
Thirteen out of 79 (16%) pregnancies had spontaneous abortions; in the other 66/79 (84%) APOs occurred in 29/66 (44%) pregnancies. Seventeen of them were SGA infants. Glucocorticoid treatment at medium-high-dosage was associated with an increased risk for APO (OR 4.431, p-value 0.018) and for SGA infants (OR 4.401, p-value 0.019). Preterm delivery (7/43, 16% versus 7/23, 30%), hypertension and/or preeclampsia (4/43, 9% versus 5/23, 22%) were observed with a lower incidence in those pregnancies occurring after 2010.