Abstract

1. Abstract
1.1. Background: Pancreatic neuroendocrine neoplasms (PNENs) are exceedenly rare, often diagnosed incidentally or with nonspecific symptoms, rarely with symptoms of hormone overproduction. The aim of this study is to evaluate the role of endoscopic ultrasound (EUS) in the diagnosis of these tumors.
1.2. Materials and methods: 5 PNENs cases were identified, between March 2017 and February 2022. EUS was performed in all patients and tissue samples were obtained using EUS -fine needle aspiration (FNA).
1.3. Results: mean age was 51 years, 80% were male, 80 % of the tumors were non-functioning PNENs. The median size was 45 mm, located in the pancreatic head in 60 % of cases. The echoendoscopic aspect was heterogeneous hypoechoic in all cases. 40% had metastases. EUS- FNA allowed tissue acquisition.
1.4. Conclusion: EUS is a sensitive tool in the diagnosis of PNENs, it identifies the lesions, evaluates their extention and allows tissue acquisition for diagnosis confirmation and prognosis.