Abstract

Stroke in young is now a major health concern in developing countries along with Coronary Artery Disease (CAD). Among the undetermined etiological factors thrombophilic disorders constitute 60% cases of stroke. Hyperhomocysteinemia is generally acknowledged as a treatable risk factor for atherotrombotic diseases, but a causal relationship between both is not yet definitively established. It has been associated with various vascular diseases including premature peripheral vascular, cerebrovascular, and coronary artery disease. It originates from a deviation in the methionine-homocysteine metabolism including disturbances of enzymes, vitamin deficiencies and different other factors.