Abstract

Asthma is a chronic inflammatory disease damaged the respiratory system, which has recently been relatively prevalent in developing countries. The presence of inflammatory and intramuscular factors in the smooth muscles of the airway walls may lead to narrowing of these channels. Substance P is a member of neurokinin family with 11 amino acids that causes pain relief and has various effects on the smooth muscles of the respiratory airways. In this study, the level of substance P, spirometric parameters and arterial blood gases were analyzed in 60 patients with asthma (30 males and 30 females) with mean age 63.67 ± 14.61 years in 2018 at 17-e-shahrivar hospital (Mashhad, Iran). After completing the written consent and the information form, the levels of substance P, pH, O2 and CO2 pressure, bicarbonate, as well as vital capacity, forced vital capacity and FEV1 were evaluated.