Abstract

Liver Transplantation (LT) has been used for patients with endstage liver disease and hepatic malignancy. Thrombocytopenia is a common complication following LT. Chatzipetrou et al. reported in a study including 541 LT recipients that90.9% of the cases had 56.5%+/-23.5% fall in platelets within the first 2 weeks and may exceed preoperative levels during 3rd or 4th post-operative weeks. Nadir of post-LT thrombocytopenia may be on Postoperative Days (PODs) 3-5 [1, 2]. The suggested mechanism for post-LT thrombocytopenia includes hemodilution, decreased Thrombopoietin (TPO) production, increased platelet sequestration in the liver graft or spleen, immunological reactions, platelet consumption due to venous thrombosis or Disseminated Intravascular Coagulation (DIC), Thrombotic Micro Angiopathy (TMA), drug-induced, various infections and complex factors [3].